Dapk1 promoted inflammation of infantile pneumonia by p38MAPK/NF-κB signaling pathway

The present study was designed to investigate the function of death-associated protein kinase 1 (DAPK1) in infantile pneumonia and explore potential mechanism actions. Male C57BL/6 mice were injected with 2 mg/kg LPS for model pneumonia. A549 cells treated 100 ng/ml vitro Dapk1 mRNA expressions 6, 12 or 24 h after induction mice. gene increased inflammation through activation p38MAPK-mediated NF-κB expression. inhibition p38MAPK reduced pro-inflammation effects DAPK1 Our demonstrates that promoted by p38MAPK/NF-κB signaling pathway, may be achieved pathway.